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Paraneoplastic neurological syndromes are usually defined as remote effects of cancer not caused by the direct spread of cancer and its metastases nor by vascular, metabolic or treatment related effects. Recently different autoantibodies were identified, both in sera and in cerebro-spinal fluid of patients affected by paraneoplastic neurological syndromes. |
| Although the role of these autoantibodies in the pathogenesis of the various syndromes is still unclear, their detection has become a useful tool both for diagnosing neurological disorders and for directing the search of underlying tumors. For these reasons it is important to investigate and discover new autoantibodies through immunohistochemistry and immunoblot. |
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